Versatile nutrient supports mood regulation, joints, and liver function*


Benefits & Features:

-Promotes healthy mood, cognition, and emotional wellbeing†

-Major source of methyl groups used by the brain in the synthesis of neurotransmitters†

-Supports joint comfort and mobility, cellular detoxification, and liver function†

-Supports numerous energy-requiring processes within your body, promoting healthy mood, cognition, and emotional well-being.† In numerous clinical studies, SAMe has also been shown to support bone and joint health, liver detoxification, and healthy cell membranes.†

Detailed Overview
SAMe (S-adenosylmethionine) is a natural compound made in the body from the essential amino acid L-methionine. It is involved in a number of body processes, including membrane function, neurotransmission, liver detoxification, and bone and joint health.† Although SAMe can be synthesized in the body, it is dependent upon the presence of sufficient levels of other nutrients including methionine, folic acid, and vitamin B12. Dietary supplementation of SAMe is an effective way to support optimal levels of this compound. 

Low levels of SAMe may result in lowered serotonin levels, a brain chemical that supports mood and emotional well-being. SAMe is also required for nerve regeneration. SAMe has been shown in numerous controlled clinical trials to support a healthy mood.† SAMe has been shown in animal studies to support cartilage growth and repair. In numerous human clinical trials, SAMe has demonstrated benefits for joint structure and function comparable or superior to those of other sulfur-containing nutrients such as glucosamine sulfate, chondroitin sulfate, and MSM.† Research suggests that the mechanism of action behind this benefit may be due to this compound’s support of cartilage formation.†

Suggested Use:
Adults take 1 tablet, 1 to 6 times daily on an empty stomach or as directed by a healthcare professional.


Serving Size: 1 Tablet

Amount Per Serving
S-Adenosyl L-Methionine ... 200mg
(from 400 mg of S-Adenosyl L-Methionine tosylate disulfate)

Other Ingredients: Microcrystalline cellulose, magnesium silicate, food glaze, magnesium stearate, stearic acid, magnesium hydroxide, glycerol, silicon dioxide, arginine, sodium alginate, and calcium oxide.


Made without common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat/gluten, soybeans, and sesame. No synthetic colors, flavors, or preservatives. Non-GMO.

Caution: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your healthcare professional before using this product.  Individuals being treated for neurological conditions, including those using prescribed medications such as antidepressants, serotonin reuptake inhibitors, and monoamine oxidase (MAO) inhibitors should consult their healthcare professional before using this product. Individuals with bipolar disorder or manic depression should not take SAMe 200 unless under medical supervision. Keep out of reach of children.